EEF1A1 (387-394) (Multiple species) (TFA) NEW
| Price | $50 | $143 | $235 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: EEF1A1 (387-394) (Multiple species) (TFA) | Purity: 100% |
| Supply Ability: 10g | Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | EEF1A1 (387-394) (Multiple species) (TFA) |
| 描述 | eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) is Elongation factor 1 subunit.eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in the brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in the brain, heart, and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes1. |
| 體外活性 | There are two forms of eEF1A in eukaryotes, eEF1A1 and eEF1A2, both of which possess the same role in protein synthesis2. eEF1A2 was reported to be exclusively expressed in the brain, heart, and skeletal muscle, whereas eEF1A1 is well known to be ubiquitously expressed3. Tetraploid cells produced by impaired chromosomal condensation are eliminated by a novel type of cell death different from caspase-dependent apoptosis. Cell death was associated with the downregulation of eukaryotic translation elongation factor-1 a 1 (eEF1A1/EF-1a) expression in conjunction with the accumulation of its mRNA in processing bodies (P bodies). Importantly, expression of exogenous eEF1A1 was shown to inhibit the caspase-independent cell death, and similar cell death was observed after inducing the expression of short hairpin RNA speci?c for eEF1A12. |
| 存儲(chǔ)條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10.41 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | eukaryotic translation elongation factor 1 alpha 1 (EEF-1A1) (387-394) [Multiple species]（TFA) | eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387394) [Multiple species]（TFA) | eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387 394) [Multiple species]（TFA) |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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