Edonerpic maleate NEW
| Price | $40 | $60 | $123 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Edonerpic maleate | CAS No.: 519187-97-4 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Edonerpic maleate |
| 描述 | Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ). |
| 細胞實驗 | A cortical neuron/glia coculture is prepared. Edonerpic maleate (T-817MA) is added to the cocultures at concentrations of 0 (control), 0.01, 0.1, and 1 μM, and the cells are subsequently incubated for 5 min or 24 h. H2O2 is then added to the coculture at a concentration of 100 μM, and the cells are incubated for another 24 h. For the normal group, the preparations are maintained in the medium with neither Edonerpic maleate nor H2O2. Neuronal cell viability is quantified by measuring the Monoclonal anti-microtubule-associated protein 2 (MAP2) immunoreactivity |
| 動物實驗 | Edonerpic maleate (T-817MA) (high-dose: 8.4 mg/kg and low-dose: 0.84 mg/kg) and donepezil (0.5 mg/kg) are dissolved in distilled water in a volume of 5 mL/kg.Wistar rats (7 weeks, n=47) are used in this study. All rats are given food and water ad libitum in a clear cage and handled on three consecutive days before start of the experiments. The housing area is provided a temperature-controlled environment under a 12/12 h light cycle. These rats are divided into five groups: vehicle (n=11), Aβ infusion control (n=10), Aβ infusion+high-dose Edonerpic maleate (T-817MA) (8.4 mg/kg) (n=11), Aβ infusion+low-dose Edonerpic maleate (0.84 mg/kg) (n=9) and Aβ infusion+donepezil (0.5 mg/kg) (n=7) |
| 體外活性 | Treatment with Edonerpic maleate (T-817MA) effectively preserves cortical neurons against Aβ(1-42) damage. By pre-treating for twenty-four hours and maintaining continuous exposure, Edonerpic maleate safeguards neurons from oxidative stress-induced death and nearly completely inhibits GSH reduction at both 0.1 and 1 μM concentrations. Furthermore, hippocampal slices exposed to 1 μM of Edonerpic maleate exhibit a significant increase in the generation and elongation of neurites compared to untreated controls, with notable enhancements in neurite length observed at concentrations of 0.1 and 1 μM. |
| 體內(nèi)活性 | The post hoc analysis revealed that the average density of PSA-positive cells was significantly higher in both the vehicle and the Aβ infusion plus high-dose Edonerpic maleate (T-817MA) groups compared to the Aβ infusion control group (P<0.01). These findings suggest that the vehicle and Aβ infusion combined with high-dose Edonerpic maleate groups not only demonstrate enhanced learning capabilities in the place learning task (PLT) but also show increased neurogenesis. However, the administration of Edonerpic maleate and donepezil did not lead to a significant change in the average density of normal granule cells, indicating no notable differences in granule cell density between the Aβ infusion control group, and the groups treated with Aβ infusion plus high-dose Edonerpic maleate, Aβ infusion plus low-dose Edonerpic maleate, and Aβ infusion plus donepezil. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 155 mg/mL (380 mM) |
| 關(guān)鍵字 | Inhibitor | β-amyloid peptide | T 817 Maleate | Abeta | Amyloid-β | Edonerpic Maleate | T 817 | Edonerpic | T817 | Edonerpic maleate | T-817 | inhibit | T817 Maleate | T-817 Maleate |
| 相關(guān)產(chǎn)品 | Anle138b | BSBM7 | Notoginsenoside R1 | Geniposide | Deferoxamine Mesylate | Tramiprosate | PQM130 | Dihydroergocristine mesylate | Rutin | Ginsenoside Rg2 | Methyl tridecanoate | Ginsenoside Re |
| 相關(guān)庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 抗阿爾茨海默癥化合物庫 | 神經(jīng)信號分子庫 | ReFRAME 相關(guān)化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $20.00/1kg |
VIP5Y
|
Hebei Yanxi Chemical Co., Ltd.
|
2023-09-27 | |
| $80.00/1KG |
VIP1Y
|
hebei hongtan Biotechnology Co., Ltd
|
2024-03-18 | |
| $50.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
2024-05-20 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY