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Postion:Product Catalog >DUPA(OtBu)-OH
DUPA(OtBu)-OH
  • DUPA(OtBu)-OH

DUPA(OtBu)-OH NEW

Price $29 $68 $113
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: DUPA(OtBu)-OH CAS No.: 1026987-94-9
Purity: 97.29% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱(chēng)DUPA(OtBu)-OH
描述DUPA(OtBu)-OH is a precursor of DUPA, which is used as a targeting moiety to actively deliver Docetaxel (DTX) for treating Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer, with PSMA showing high affinity for DUPA (Ki = 8 nM).
體外活性DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis.
體內(nèi)活性Histological analysis indicated that DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 125 mg/mL (255.85 mM), Sonication is recommended.
關(guān)鍵字Inhibitor | DUPA(OtBu)-OH | DUPA(OtBu)OH | DUPA(OtBu) OH | inhibit
相關(guān)產(chǎn)品Vipivotide tetraxetan | DL-Mannitol | PSMA-11 | PSMA-ALB-56
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 抗前列腺癌化合物庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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