Droperidol NEW
| Price | $39 | $55 | $91 |
| Package | 100mg | 200mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Droperidol | CAS No.: 548-73-2 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Droperidol |
| Description | Droperidol (Dehydrobenzperidol) is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist. |
| In vitro | Droperidol has a dual effect on repolarization, prolonging the development of EADs and the subsequent triggering of activity in rabbit Purkinje fibers at low concentrations. In rabbit Purkinje fibers stimulated with 60 pulses/min, 0.01 mM-0.3 mM Droperidol increased action potential duration (APD) in a dose-dependent manner without altering other parameters.1 mM-3 mM Droperidol resulted in a reversal of the prolongation effect in rabbit Purkinje fibers.10 mM- 30 mM Droperidol produced a shortening of the APD at 50% repolarization, accompanied by significant reductions in Vmax, action potential amplitude, and resting membrane potential in rabbit Purkinje fibers. A single dose of 3 mg/kg Droperidol not only dose-dependently reduced activity and rearing frequency in the open-field experiment, but also reduced the Apomorphine effect in rats.Droperidol (3 mg/kg, long-term administration) induced significant tolerance to all activity parameters recorded in the rat open field. |
| In vivo | Droperidol has been shown to block potassium efflux from the myocardium of isolated animal ventricular myocytes, resulting in a dose-dependent delay in repolarization.Droperidol also induces early depolarization of Purkinje fibers in isolated animals.Droperidol produces mild alpha-adrenergic blockade and peripheral vasodilation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 65 mg/mL (171.31 mM), Sonication is recommended. |
| Keywords | NSC169874 | Dopamine Receptor | Droperidol | inhibit | NSC-169874 | Inhibitor |
| Inhibitors Related | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Octopamine hydrochloride | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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