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Postion:Product Catalog >DPTIP
DPTIP
  • DPTIP

DPTIP NEW

Price $41 $57 $97
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: DPTIP CAS No.: 351353-48-5
Purity: 98.80% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameDPTIP
DescriptionDPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
In vitroDPTIP (30 μM) decreases exosome release by 50% in astrocytes. DPTIP(0.03-30 μM) dose-dependently blocks EV secretion[1].
In vivoIn mice, DPTIP potently (10?mg/kg; i.p.) inhibits IL-1β-induced astrocyte-derived EV release. Brain concentrations of DPTIP are above its IC50 for neutral sphingomyelinase 2 inhibition for at least 4?h after the administration of DPTIP[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 245 mg/mL (647.39 mM), Sonication is recommended.
Keywordsextracellular | Inhibitor | exosome | Phospholipase | DPTIP | vesicles | inhibit | N-SMase
Inhibitors RelatedNeomycin sulfate | 1-Naphthaleneacetic acid potassium salt | trans-Benzylideneacetone | Benzylideneacetone | Tris(2,4-di-tert-butylphenyl)phosphate | (E/Z)-Polydatin | Indomethacin | Fluticasone (propionate) | 1-Naphthaleneacetic acid | Darapladib | Lansoprazole | Amentoflavone
Related Compound LibrariesBioactive Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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