DL-Sulforaphane N-acetyl-L-cysteine NEW
| Price | $110 | $483 | $853 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-06 |
Product Details
| Product Name: DL-Sulforaphane N-acetyl-L-cysteine | CAS No.: 334829-66-2 |
| Supply Ability: 10g | Release date: 2025/05/06 |
Product Introduction
Bioactivity
| Name | DL-Sulforaphane N-acetyl-L-cysteine |
| Description | DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC). |
| In vitro | In studies on U87MG and U373MG cells, treatment with DL-Sulforaphane N-acetyl-L-cysteine (30 μM) for 24 hours resulted in cell cycle analysis showing drug-induced G2/M phase arrest, along with the initiation of apoptosis. In the same cell lines, Western blot analysis revealed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 10 to 50 μM, activated ERK1/2 (Thr202/Tyr204), downregulated α-tubulin, and induced autophagy in a dose-dependent manner. Additionally, cell viability assays showed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 0 to 90 μM, decreased the viability of HA cells, U87MG cells, and U373MG cells in a dose-dependent manner, with IC50 values of 60.08 μM, 35.20 μM, and 39.11 μM, respectively[1]. |
| In vivo | In the HDAC inhibition model, DL-Sulforaphane N-acetyl-L-cysteine (10 μmol, oral gavage, single dose, 6-hour treatment) significantly inhibited histone deacetylase (HDAC) activity in the colon mucosa of mice[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 8.00 mg/mL (23.50 mM), Sonication is recommended. PBS (pH 7.2) : 8.00 mg/mL (23.50 mM), Sonication is recommended. Ethanol : 4.00 mg/mL (11.75 mM), Sonication is recommended. DMF : 8.00 mg/mL (23.50 mM), Sonication is recommended. |
| Keywords | DL-Sulforaphane N-acetyl-L-cysteine | DLSulforaphane NacetylLcysteine | DL Sulforaphane N acetyl L cysteine |
| Inhibitors Related | TBHQ | Notoginsenoside R1 | Tamoxifen | Lidocaine | Astragaloside IV | Lidocaine hydrochloride | Honokiol | Tauroursodeoxycholate | Rifabutin | Palmitic acid | Paeoniflorin | Nisin Z |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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