Disodium D-3-phosphoglycerate is a chemical compound that is the disodium salt of D-3-phosphoglyceric acid. It plays a role in biochemical processes, particularly in glycolysis, which is a critical metabolic pathway for energy production in cells.

Chemical Structure and Properties

• Chemical Formula: C3H5Na2O7P

• Molecular Weight: Approximately 242.02 g/mol

• Structure: The molecule consists of a glyceric acid backbone with a phosphate group attached to the third carbon and two sodium ions balancing the negative charge of the phosphate group.

• Appearance: Typically appears as a white crystalline powder.

• Solubility: Soluble in water, forming a clear solution.

• Stability: Stable under normal conditions when stored properly in a cool, dry place.

Biological Role and Applications

1. Biochemical Research

• Application: Disodium D-3-phosphoglycerate is often used in biochemical research and studies related to glycolysis and other metabolic pathways.

• Role in Glycolysis: It is an intermediate in the glycolytic pathway, specifically involved in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, a process catalyzed by the enzyme phosphoglycerate kinase.

2. Metabolic Studies

• Application: Used in studies focusing on energy production, metabolism, and enzymatic reactions related to the glycolytic pathway.

• Importance: Understanding the role of intermediates like disodium D-3-phosphoglycerate helps researchers develop insights into cellular energy production and related disorders.

3. Potential Therapeutic Research

• Application: Although not a drug itself, intermediates like disodium D-3-phosphoglycerate may be studied in the context of developing treatments for metabolic disorders, where the regulation of glycolysis is crucial.

Safety and Handling

• Toxicity: There is limited specific toxicity information available for disodium D-3-phosphoglycerate, but as with many chemicals used in research, it should be handled with care to avoid ingestion, inhalation, or skin contact.

• Handling: Standard laboratory safety procedures should be followed, including the use of gloves, goggles, and protective clothing.

• Storage: Should be stored in a tightly closed container, protected from light and moisture, in a cool, dry environment.

Summary

Disodium D-3-phosphoglycerate is a disodium salt form of a key intermediate in the glycolytic pathway. It is used primarily in biochemical research to study metabolism, energy production, and enzymatic processes. While its primary application is in research settings, it plays an important role in understanding the fundamental processes of cellular energy production. Proper handling and storage are required to ensure its stability and safety in use.

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