Dihydroartemisinin NEW
| Price | $33 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Dihydroartemisinin | CAS No.: 71939-50-9 |
| Purity: 99.72% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱(chēng) | Dihydroartemisinin |
| 描述 | Dihydroartemisinin (Artenimol) is a metabolite of artemisinin. |
| 細(xì)胞實(shí)驗(yàn) | BxPc3-RFP cells (3.5×104cells/well) were seeded in poly D-lysine-coated black, μClear 96-well plates with 0.2 ml medium. After 24 h, the cells were treated with dimethyl sulfoxide (DMSO) (control) or different concentrations (2.5, 10, 40, or 80 μM) of DHA dissolved in DMSO for 24, 48, and 72 h. At each time point, the fluorescence intensity emitted from cells was measured. (Only for Reference) |
| 體外活性 | Dihydroartemisinin (DHA) inhibits the growth of certain cancer cell lines and xenograft tumors such as leukemia, glioma, fibrosarcoma, and breast, cervical, ovarian, lung, oral and pancreatic cancer. DHA inhibits cell and tumor growth by modulating various tumor-suppressive pathways, such as inhibiting cell proliferation and inducing apoptosis through regulation of proliferation- and apoptosis-related proteins.DHA inhibits the proliferation and viability of cells in a dose-dependent manner and induces apoptosis.DHA-mediated cytotoxicity is tumor selective. The endoperoxide bridge of DHA is reportedly essential for its cytotoxicity because it reacts with intracellular ferrous iron to generate reactive oxygen species or carbon-centered radicals, leading to cytotoxicity[1]. |
| 體內(nèi)活性 | DHA significantly inhibited HCC cell growth in vitro and in vivo via inducing G2/M cell cycle arrest and apoptosis[2]. DHA has been shown in the rat whole embryo culture (WEC) to primarily affect primitive red blood cells (RBCs) causing subsequent tissue damage and dysmorphogenesis[3]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 9 mg/mL (31.7 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.2 mg/mL (18.29 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 8.13 mg/mL (28.57 mM), Sonication is recommended. |
| 關(guān)鍵字 | Autophagy | Apoptosis | inhibit | Parasite | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | Dihydroartemisinin | b-Dihydroartemisinin | beta-Dihydroartemisinin | Inhibitor |
| 相關(guān)產(chǎn)品 | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Doxycycline | Tributyrin | Paeonol | Naringin |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 抗寄生蟲(chóng)庫(kù) | 萜類(lèi)天然產(chǎn)物庫(kù) | 中藥單體化合物庫(kù) | 抗癌臨床化合物庫(kù) | 天然產(chǎn)物庫(kù) | 中藥抗炎分子庫(kù) | 抗衰老化合物庫(kù) | 抗病毒中藥單體化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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