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Postion:Product Catalog >DHODH-IN-14
DHODH-IN-14
  • DHODH-IN-14

DHODH-IN-14 NEW

Price $117 $175 $269
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: DHODH-IN-14 CAS No.: 1364791-93-4
Purity: 99.87% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱DHODH-IN-14
描述DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
體外活性DHODH-IN-14 is a hydroxyfuran analog of A771726, which contains a biphenyl scaffold with a fluorine substituent. Turning to the derivative DHODH-IN-14, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, it was found that DHODH-IN-14 was bound in a BQN-like manner, that is, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. Although it was not found on 1D3G and 1UUO that hydroxyfuran interacted with Tyr356 in a similar way to leflunomide, when 2BXV was used as a docking target, a large portion of such postures were found[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 50 mg/mL (141.55 mM)
關(guān)鍵字DHODH-IN-14 | DHODHIN14 | DHODH IN 14
相關(guān)產(chǎn)品Disulfiram | Methotrexate | ALDH1A3-IN-3 | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | Sodium Oxamate | Ivosidenib
相關(guān)庫經(jīng)典已知活性庫 | 抗癌細(xì)胞代謝庫 | 抑制劑庫 | 線粒體靶向庫 | 代謝化合物庫 | 免疫/炎癥分子化合物庫 | 已知活性化合物庫 | 含氟化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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