DG172 dihydrochloride NEW
| Price | $34 | $55 | $97 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: DG172 dihydrochloride | CAS No.: 1361504-77-9 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | DG172 dihydrochloride |
| 描述 | DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM). |
| 體外活性 | DG172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC(50) = 27 nM) and potent inverse agonistic properties.?DG172 selectively inhibited the agonist-induced activity of PPARβ/δ, enhanced transcriptional corepressor recruitment, and down-regulated transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC(50) = 9.5 nM).?Importantly, DG172 was bioavailable after oral application to mice with peak plasma levels in the concentration range of its maximal inhibitory potency, suggesting that 37 will be an invaluable tool to elucidate the functions and therapeutic potential of PPARβ/δ[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 14.29 mg/mL (31.39 mM), Sonication is recommended. |
| 關(guān)鍵字 | DG 172 | DG172 dihydrochloride | PPAR | DG172 | inhibit | DG 172 Dihydrochloride | DG172 Dihydrochloride | Inhibitor | Peroxisome proliferator-activated receptors | DG-172 Dihydrochloride | DG-172 |
| 相關(guān)產(chǎn)品 | PHYTOL | (S)-(+)-Ibuprofen | BADGE | Cinnamyl alcohol | Daidzein | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin |
| 相關(guān)庫(kù) | DNA 損傷和修復(fù)分子庫(kù) | 抗胰腺癌化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 代謝化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 共價(jià)抑制劑庫(kù) | 抗代謝疾病化合物庫(kù) | 轉(zhuǎn)錄因子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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