Dexmedetomidine hydrochloride NEW
| Price | $35 | $50 | $90 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Dexmedetomidine hydrochloride | CAS No.: 145108-58-3 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Dexmedetomidine hydrochloride |
| 描述 | Dexmedetomidine hydrochloride (Precedex) is a potent, selective, orally active α2-adrenoceptor agonist with a Ki value of 1.08 nM. It shows 1620-fold selectivity over α1-adrenoceptors. Dexmedetomidine hydrochloride (Precedex) can protect against sepsis-induced acute lung injury through anti-inflammatory, anti-oxidative, and anti-apoptotic effects. |
| 激酶實驗 | In vitro HDAC assay:HDAC activity is analyzed by using an HDAC assay kit. This assay is based on the ability of DU-145 nuclear extract, which is rich in HDAC activity, to mediate the deacetylation of the biotinylated [3H]-acetyl histone H4 peptide that is bound to streptavidin agarose beads. The release of [3H]-acetate into the supernatant is measured to calculate the HDAC activity. Sodium butyrate (0.25-1 mM) is used as a positive control. |
| 體外活性 | METHODS: NR8383 alveolar macrophages were stimulated with 10 μg/ml LPS for 24 hours and then treated with Dexmedetomidine hydrochloride (Precedex) (0.01, 0.1, 1, 10, 50 μM, 2 hours) for another 2 hours. CCK-8 assay was used to evaluate the effect of different concentrations of Dexmedetomidine hydrochloride (Precedex) pretreatment on the viability of LPS-treated NR8383 cells. RESULTS Cell viability gradually increased with increasing concentrations of Dexmedetomidine hydrochloride (Precedex). [1] |
| 體內(nèi)活性 | METHODS: Using C57BL/6J mice exposed to LPS, we investigated whether Dexmedetomidine hydrochloride (Precedex) (50 μg/kg, intraperitoneal injection) provides lung protection by regulating mitochondrial dynamics via the HIF-1a/HO-1 pathway in vivo. RESULTS Dexmedetomidine hydrochloride (Precedex) alleviated lung pathological damage, reduced the oxidative stress index (OSI), improved mitochondrial dysfunction, upregulated the expression of HIF-1α and HO-1, and was accompanied by a shift in mitochondrial dynamics to fusion. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (232.32 mM) H2O : 23.7 mg/mL (100 mM) |
| 關(guān)鍵字 | inhibit | Inhibitor | adrenoceptor | (+)-Medetomidine | Dexmedetomidine hydrochloride | Dexmedetomidine | analgesia | sedation | Beta Receptor | Adrenergic Receptor | anxiolysis | (S)-Medetomidine | Dexmedetomidine Hydrochloride | Medetomidine Hydrochloride |
| 相關(guān)產(chǎn)品 | Octopamine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| 相關(guān)庫 | 神經(jīng)退行性疾病化合物庫 | EMA 上市藥物庫 | 抗癌臨床化合物庫 | FDA 上市藥物庫 | 抗癌上市藥物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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