Chinese name: Desherilin

English name: Deslorelin

CAS: 57773-65-6

Molecular formula: C64H83N17O12

MDL number: MFCD00167401

Molecular weight: 1282.45

Appearance: white powder. The biological activity is dozens of times stronger than that of natural LH-RH.

Melting point: >189oC

Specific rotation: D24-61 ° (c = 0.37 in 0.1M acetic acid)

Density: 1.48± 0.1g /cm3(Predicted)

Storage condition: ?20°C

Solubility: acetic acid (slightly soluble), DMSO (slightly soluble), methanol (slightly soluble)

Predicted Acidity coefficient (pKa) : 9.82±0.15

Form: solid

Color: White to off-white

Sequence: Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt

InChIKey: GJKXGJCSJWBJEZ-QCOVUDKBNA-N

use

Biochemical research; It is clinically used to treat prostate cancer

Preparation method

The corresponding protective amino acid monomer was used as raw material to synthesize by solid-phase or liquid-phase synthesis.