Description of Deoxycorticosterone acetate from Wuhan Fortuna Chemical Co.,Ltd

Specifications(COA) of Factory Supply Active Pharmaceutical Ingredient Deoxycorticosterone acetate CAS NO 56-47-3 High Assay 99.1%

Introduction of Deoxycorticosterone acetate.

Deoxycorticosterone acetate (DOCA) is a synthetic steroid hormone. It's a derivative of the naturally occurring hormone aldosterone, which is produced in the adrenal glands and plays a key role in regulating electrolyte and fluid balance in the body, particularly by increasing the reabsorption of sodium ions and water and by excreting potassium ions.

DOCA has been used in medical settings for its mineralocorticoid effects, particularly in experimental studies of hypertension and kidney function. It has also been used in certain medical treatments, although its clinical use has declined over the years due to the availability of more specific and effective drugs.

Application of Deoxycorticosterone acetate.

Deoxycorticosterone acetate (DOCA) has been used in various medical applications, primarily due to its mineralocorticoid properties. Some of its historical and current applications include:

Experimental Studies: DOCA has been extensively used in experimental studies, particularly in animal models, to investigate hypertension, kidney function, and electrolyte balance. Researchers have used DOCA to induce hypertension in animals for studying its mechanisms and potential treatments.

Treatment of Adrenal Insufficiency: In the past, DOCA has been used as a replacement therapy for adrenal insufficiency (Addison's disease). However, its use for this purpose has largely been replaced by more specific glucocorticoid and mineralocorticoid replacements.

Research Tool: DOCA is often used as a research tool in laboratory studies to manipulate mineralocorticoid levels and study their effects on various physiological processes, such as kidney function, blood pressure regulation, and electrolyte balance.

Animal Models of Hypertension: DOCA has been used to induce hypertension in animal models for studying the pathophysiology of hypertension and testing potential therapeutic interventions.

Studying Salt Sensitivity: DOCA has been used to induce salt-sensitive hypertension in animal models, allowing researchers to study the mechanisms underlying salt sensitivity and its relationship to hypertension and cardiovascular disease.

Overall, while DOCA has been valuable in research settings for studying various aspects of physiology and disease, its clinical use has diminished over time due to the availability of more specific and effective drugs for treating conditions such as adrenal insufficiency and hypertension.

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