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Postion:Product Catalog >API>Antiparasitic drugs>Antiamoebic and anti-trichomoniasis drugs>Dehydroemetine
Dehydroemetine
  • Dehydroemetine

Dehydroemetine NEW

Price $129 $322 $487
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-13

Product Details

Product Name: Dehydroemetine CAS No.: 4914-30-1
Purity: 99.58% Supply Ability: 10g
Release date: 2024/11/13

Product Introduction

Bioactivity

名稱Dehydroemetine
描述Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania infection with skin damage and resistance to metronidazole amoebiosis.
體內(nèi)活性The mechanism of the inhibitory effect of Dehydroemetine on the heart was investigated using (a) the spontaneously contracting isolated guinea-pig atrial preparation and (b), the electrically driven left atrial preparation. Dehydroemetine decreased the rate and amplitude of contraction of spontaneously contracting atria. Increasing the calcium concentration of the bath fluid to 28.2 mM abolished the effect of Dehydroemetine on the amplitude of contraction while the effect on the rate persisted. Pretreatment with Dehydroemetine increased the capacity of ouabain to induce arrhythmias in spontaneously contracting atria. Similarly, pretreatment with ouabain augmented the inhibitory effect of Dehydroemetine on spontaneous atrial activity. In the electrically driven left atrial preparation, Dehydroemetine caused a decrease in contractile strength which was opposed by ouabain and by increased calcium concentration of the bath fluid. The effect of Dehydroemetine on spontaneously contracting and on electrically driven atria was mimicked by adding excess potassium to the bath fluid. It was concluded that the effects of Dehydroemetine on rate and contractility are, to a large extent, independent of one another. The effect on spontaneous rate is consistent with alteration of the potassium permeability of the myocardial cell membrane while the effect on contractility appears to be due to a decrease in the uptake of calcium from the medium by the myocardial cell.[1]
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 25 mg/mL (52.23 mM), Sonication is recommended.
關(guān)鍵字Dehydroemetine
相關(guān)產(chǎn)品Kaempferol | Hydroxychloroquine | Metronidazole | Nitazoxanide | Doxycycline | Chloroquine phosphate | Diethyltoluamide | Artemisinin | Benzyl benzoate | DL-Methionine
相關(guān)庫抗寄生蟲庫 | 經(jīng)典已知活性庫 | 抗寄生蟲天然產(chǎn)物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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