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Postion:Product Catalog >DCC-3116
DCC-3116
  • DCC-3116

DCC-3116 NEW

Price $195 $483 $692
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: DCC-3116 CAS No.: 2543673-19-2
Purity: 98.80% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱DCC-3116
描述DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.
體外活性100 nM DCC-3116 alone inhibited NCI-H2122 and Calu-1 cell proliferation and reduced pS318-ATG13 expression, and DCC-3116 in combination with sotorasib showed synergistic inhibition of human lung cancer cell proliferation driven by the KRAS G12C mutation in vitro. [1]
體內(nèi)活性Daily oral or intraperitoneal administration of 3 or 30 mg/kg DCC-3116 for 56 consecutive days alone or in combination with Sotorasib inhibited tumor growth in a mouse model of NSCLC lung cancer. [1]
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL(186.71 mM), Sonication is recommended.
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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