Dapagliflozin NEW
| Price | $42 | $58 | $91 |
| Package | 5mg | 10mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Dapagliflozin | CAS No.: 461432-26-8 |
| Purity: 99.74% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Dapagliflozin |
| 描述 | Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. |
| 細(xì)胞實驗 | To perform the cell survival assay, cells are collected after 24 h incubation with vehicle or dapagliflozin pretreatment in 30-min ischemia and surviving cells are counted with Trypan blue staining. The percentage survival is determined by quantization of the relative viable number of treated cells divided by the viable number of untreated cells. |
| 體外活性 | METHODS: The human proximal tubule epithelial cell line HK2 was treated with Dapagliflozin (1-10 μM) under normoxic and hypoxic conditions for 24 h. Cell viability was assayed using Trypan blue staining. RESULTS: Dapagliflozin pretreatment had no effect on cell survival of normoxic HK2 cells. Hypoxia significantly reduced the cell viability of HK2 cells compared to control cells, and Dapagliflozin pretreatment of hypoxic HK2 cells significantly increased cell viability in a dose-dependent manner. [1] METHODS: The human proximal tubule epithelial cell line HK2 was treated with Dapagliflozin (0.1 μM) and H2O2 (200 μM) for 24 h. Apoptosis was detected using Hoechst 33342 and PI. RESULTS: Dapagliflozin significantly reduced the percentage of apoptotic cell death induced by H2O2.Dapagliflozin had a protective effect against H2O2-induced cell death. [2] |
| 體內(nèi)活性 | METHODS: To investigate the effects on diabetic atherosclerosis, Dapagliflozin (1 mg/kg) was administered by gavage to diabetic ApoE-/- mice with high-fat diet-induced atherosclerosis once daily for 12 weeks. RESULTS: Dapagliflozin may have therapeutic potential for high-fat diet-induced diabetic atherosclerosis, and these benefits may depend on the inhibition of IL-1β secretion by macrophages via the ROS-NLRP3-caspase-1 pathway. [3] |
| 存儲條件 | store at low temperature,store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 14 mg/mL (34.2 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 45 mg/mL (110.06 mM) |
| 關(guān)鍵字 | BMS512148 | Sodium-dependent glucose cotransporters | SGLT | inhibit | BMS 512148 | Inhibitor | Dapagliflozin |
| 相關(guān)產(chǎn)品 | Dapagliflozin ((2S)-1,2-propanediol, hydrate) | DMOG | PT-2385 | Roxadustat | Hydroxycitric acid tripotassium hydrate | Phlorizin | Empagliflozin | Oltipraz | Acriflavine Hydrochloride | Cinnamaldehyde |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | FDA 上市藥物庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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