Tetrandrine a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a "Quinidine like" anti-arrhythmic effect. It has been isolated from Stephania tetrandra S Moore, and other Chinese and Japanese herbs. It has vasodilatory properties and can therefore reduce blood pressure. Tetrandrine may have potential use for the treatment of liver disease and liver cancer. Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation. Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells in vitro and showed therapeutic efficacy against Ebola in preliminary studies on mice.

Appearance and properties: white solid

Density: 1.17g /cm3 (20oC)

Boiling point: 710.5oC at 760 mmHg

Melting point: 219-222oC

Flash point: 175.8oC

Refractive index: 1.585

Stability: Stable at normal temperatures and pressures.

Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20oC.

Use

Antirheumatic and analgesic drugs used in the treatment of rheumatism, hypertension, lung cancer and other diseases