Cyproheptadine hydrochloride, also known as diphenylcycloheptadine, metadonidine, ethylphenycloheptadine, antigon, is a hexahydropyridine antihistamine, which can compete with histamine released in the tissue for the H1 receptor on the effect cell, thereby preventing the attack of allergic reaction, relieving the spasmodic and congestion effect of histamine. This product has a strong H1 receptor antagonism. The antihistamine effect is stronger than promethamine and promethazine. It has mild and moderate anti-serotonin and anti-cholinergic effects. In addition, there is a role in stimulating appetite, and weight gain can be seen after a certain period of time.

Clinical application

Clinically, cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially cold urticaria has a good effect), papular urticaria, vascular edema, allergic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, insect sting allergy and migraine. It has certain therapeutic effect on bronchial asthma. Can also be used for Cushing syndrome, acromegaly adjuvant treatment. It can also be used as an appetite enhancer for nervous fear of food. There are reports of treating acanthosis nigricans and preventing necrotizing pyoderma.

Side effect

1. After the drug may appear drowsiness or drowsiness, dry mouth, bitter mouth, thick sputum, constipation, etc. There were also reports of rash, increased photosensitivity, hypotension, tachycardia, extrasystole, anaphylactic shock, hemolytic anemia, leukopenia, thrombocytopenia, fatigue, headache, insomnia, paresthesia, convulsion, hallucination, hysteria and other adverse reactions.

2. Long-term medication may lead to increased appetite and weight gain.