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Postion:Product Catalog >Biochemical Engineering>Amino Acids and proteins>Cycloleucine
Cycloleucine
  • Cycloleucine

Cycloleucine NEW

Price $39 $55 $80
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Cycloleucine CAS No.: 52-52-8
Purity: 98.13% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameCycloleucine
DescriptionCycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects.
In vitroCytostatic (10 μg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[2].
In vivoCycloleucine (0.5, 1.0, 2.0, 4 μg/μL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3]. In Semliki Forest virus strain A7(74) infected and control mice, Cycloleucine reduces thymus and spleen weights[4].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 45 mg/mL (348.41 mM), Sonication is recommended.
DMSO : < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.
KeywordsCycloleucine | inhibit | NMDA | cytostatic | Inhibitor | methylations | ATP | nucleic | Ionotropic glutamate receptors | anxiolytic | transferase | iGluR | glycine
Inhibitors RelatedHalothane | Riluzole | O-Phospho-L-serine
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Neuroprotective Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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