Cyclo(L-Phe-trans-4-hydroxy-L-Pro) NEW
| Price | $79 | $159 | $258 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Cyclo(L-Phe-trans-4-hydroxy-L-Pro) | CAS No.: 118477-06-8 |
| Purity: 99.46% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Cyclo(L-Phe-trans-4-hydroxy-L-Pro) |
| 描述 | Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline)) is a natural product found in Phellinus igniarius. |
| 體外活性 | We previously identified Streptomyces griseus as an anti-cancer agent (Kim et al., 2014). In this study, we isolated compounds from S. griseus and evaluated their anticancer effect and toxicity in vitro and in vivo. METHODS AND RESULTS: Preparative centrifugal partition chromatography (CPC) was used to obtain three compounds, cyclo(L-[4-hydroxyprolinyl]- L -leucine], Cyclo(L-Phe-trans-4-hydroxy-L-Pro) and phenethyl acetate (PA). We chose PA, which had the highest anticancer activity, as a target compound for further experiments. PA induced the formation of apoptotic bodies, DNA fragmentation, DNA accumulation in G0/G1 phase, and reactive oxygen species (ROS) formation. Furthermore, PA treatment increased Bax/Bcl-xL expression, activated caspase-3, and cleaved poly-ADP-ribose polymerase (PARP) in HL-60 cells. Simultaneous evaluation in vitro and in vivo, revealed that PA exhibited no toxicity in Vero cells and zebrafish embryos. CONCLUSIONS: We revealed, for the first time, that PA generates ROS, and that this ROS accumulation induced the Bcl signaling pathway[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (192.09 mM) |
| 關(guān)鍵字 | Cyclo(L-Phe-trans-4-hydroxy-L-Pro) |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 海洋天然產(chǎn)物庫 | 環(huán)肽庫 | 經(jīng)典已知活性庫 | 天然產(chǎn)物庫 | 微生物天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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