Product Details
| Product Name:
Cy5.5 |
CAS No.:
210892-23-2 |
| Purity:
96.69% |
Supply Ability:
10g |
| Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Cy5.5 |
| 描述 | Cy5.5 is a near-infrared fluorescent dye for labeling biomolecules such as peptides, proteins and oligonucleotides (Ex=673 nm, Em=707 nm)[2]. |
| 體外活性 | METHODS: fVIIa and anti-TF antibody were labeled with the fluorescent tag Cy5.5, and U87MG-EGFRviii glioma cells were exposed to Cy5.5-labeled fVIIa and Cy5.5-labeled anti-TF antibody in vitro. To demonstrate the specificity of fVIIa binding to TF, unbound fVIIa was incubated with Cy5.5-labeled fVIIa in vitro at a 5-fold excess.
RESULTS The images obtained showed that most of the signal of Cy5.5-labeled fVIIa was reduced by adding excess unlabeled fVIIa in vitro, indicating the specificity of binding. [1] |
| 體內(nèi)活性 | METHODS: Cy5.5-FFRck-fVIIa and Cy5.5 dye alone were injected intravenously (i.v.) into right flank athymic nude mice (nu/nu) bearing TF-expressing ASPC-1 and TF-non-expressing MiaPaCa pancreatic tumor xenografts and tested for duration and stability of binding to enable follow-up of treatment response.
RESULTS Specific localization of Cy5.5-FFRck-fVIIa to TF in VECs of pancreatic tumor xenografts was observed from day 1 to day 26 in both ASPC-1 and MiaPaCa tumors, whereas no specific localization was observed with unconjugated Cy5.5 alone.[1] |
| 存儲條件 | keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice. |
| 溶解度 | DMSO : 85 mg/mL (92.69 mM), The compound is unstable in solution. Please use soon.
|
| 關(guān)鍵字 | Inhibitor | Cy-5.5 | inhibit | Cy5.5 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/25mg |
VIP1Y
|
Xian confluore Biological Technology Co., Ltd.
|
2024-03-28 |
United States