CXCR4 antagonist 7 NEW
| Price | $2140 | $2785 | $3520 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: CXCR4 antagonist 7 | CAS No.: 1185451-72-2 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | CXCR4 antagonist 7 |
| Description | CXCR4 antagonist 7 (Compound PARA-B) is a potent CXCR4 inhibitor (IC50 = 9.3 nM) [1] applicable in research on HIV infection, inflammatory diseases, cancer, and WHIM syndrome. |
| In vitro | CXCR4 antagonist 7 (PARA-B, 10 nM to 1 μM, various durations) inhibits GH4C1 cell activities. At 10 nM to 1 μM for 20 hours, it suppresses CXCL12-stimulated GH4C1 proliferation with an IC50 of 9.3 nM. At 1 μM for 12 hours, it reduces CXCL12-dependent GH4C1 migration by 50%. At 50 nM for 30 minutes, it decreases CXCL12-induced ERK1/2 phosphorylation. It inhibits CXCL12-triggered GH4C1 proliferation and migration via CXCR4 inhibition. At 1 μM for 24 hours, no adverse effects on GH4C1 cell viability were observed. It also inhibits various cancer cell proliferations (10 nM-1 μM, 20-24 hours, IC50 values 1.08-3.45 μM) without affecting GH4C1 viability. In migration assays (50 nM-1 μM, 12 hours for GH4C1 and 30 minutes for GH4A11), it significantly reduces GH4C1 migration, with no effect on GH4A11 cells, even with CRISPR-Cas9-induced CXCR4 mRNA reduction. Western blot analysis confirms the reduction in CXCL12-induced ERK1/2 phosphorylation at 50 nM for 30 minutes. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $700.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-20 | |
| $0.00/1mg |
VIP1Y
|
Hubei Chuchang Biotech Co., Ltd.
|
2024-04-17 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY