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Postion:Product Catalog >CUDC-427
CUDC-427
  • CUDC-427

CUDC-427 NEW

Price $42 $58 $98
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-13

Product Details

Product Name: CUDC-427 CAS No.: 1446182-94-0
Purity: 98.99% Supply Ability: 10g
Release date: 2024/11/13

Product Introduction

Bioactivity

名稱CUDC-427
描述CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
體外活性In PBMCs, GDC-0917 (0.1 -10000 nM) induces the reduction of cIAP1 levels in a concentration-dependent manner. GDC-0917(0.1 μM) shows more than 80% inhibition[1].
體內(nèi)活性In the MDA-MB-231-X1.1 Breast Cancer Xenograft, GDC-0917 (0.08-16.3 mg/kg) dose-dependently exhibits antitumor activity with a <11% decrease of body weight. The clearance values are 12.0, 27.0, 15.3 and 67.6 mL/min/kg for mouse, rat, dog and monkey[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 45.0 mg/mL (79.7 mM), Sonication is recommended.
關(guān)鍵字CUDC-427 | GDC0917 | GDC 0917 | CUDC427 | CUDC 427
相關(guān)產(chǎn)品LCL161 | MX69 | Se-Methylselenocysteine | HM90822 | BV6 | 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one | AZD5582 TFA | N-Deshydroxyethyl Dasatinib | Xevinapant | Acacetin | ASTX660 | Birinapant
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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