CUDC-427 NEW
Price | $42 | $58 | $98 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-13 |
Product Details
Product Name: CUDC-427 | CAS No.: 1446182-94-0 |
Purity: 98.99% | Supply Ability: 10g |
Release date: 2024/11/13 |
Product Introduction
Bioactivity
名稱 | CUDC-427 |
描述 | CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers. |
體外活性 | In PBMCs, GDC-0917 (0.1 -10000 nM) induces the reduction of cIAP1 levels in a concentration-dependent manner. GDC-0917(0.1 μM) shows more than 80% inhibition[1]. |
體內(nèi)活性 | In the MDA-MB-231-X1.1 Breast Cancer Xenograft, GDC-0917 (0.08-16.3 mg/kg) dose-dependently exhibits antitumor activity with a <11% decrease of body weight. The clearance values are 12.0, 27.0, 15.3 and 67.6 mL/min/kg for mouse, rat, dog and monkey[1]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 45.0 mg/mL (79.7 mM), Sonication is recommended. |
關(guān)鍵字 | CUDC-427 | GDC0917 | GDC 0917 | CUDC427 | CUDC 427 |
相關(guān)產(chǎn)品 | LCL161 | MX69 | Se-Methylselenocysteine | HM90822 | BV6 | 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one | AZD5582 TFA | N-Deshydroxyethyl Dasatinib | Xevinapant | Acacetin | ASTX660 | Birinapant |
相關(guān)庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | PPI抑制劑庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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