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Postion:Product Catalog >CU-115
CU-115
  • CU-115

CU-115 NEW

Price $53 $147 $239
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: CU-115 CAS No.: 2471982-20-2
Purity: 100% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱CU-115
描述CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 μM and =>50 μM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.
體外活性CU-115 (1, 5, and 20 μM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 μM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 μM) abolishes the TNF-α production activated by R848 (1 μg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 45 mg/mL (79.06 mM), Sonication is recommended.
關(guān)鍵字CU-115 | CU115 | CU 115
相關(guān)產(chǎn)品Polyinosinic-polycytidylic acid sodium | CU-CPD107 | Imiquimod hydrochloride | Hydroxychloroquine | Chloroquine phosphate | Hydroxychloroquine sulfate | Chloranil | Chloroquine | Imiquimod | TLR3-IN-1 | Rabeximod | Resiquimod
相關(guān)庫經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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