Product Details
| Product Name:
Cofrogliptin |
CAS No.:
1844874-26-5 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Cofrogliptin |
| Description | Cofrogliptin (HSK7653) is an orally available dipeptidyl peptidase-4 (DPP-4) inhibitor with hypoglycemic effects, which can be used to study type 2 diabetes (T2D). |
| In vitro | Evaluate the DPP-4 inhibitory activities of Cofrogliptin, Cofrogliptin exhibited a much better in vitro activity, which significantly enhanced the potency IC50 = 4.2 nM. [1] |
| In vivo | In vehicle group, mice were intragastrically given 1% hypromellose at a volume of 20 mL/kg. In treatment groups, mice were intragastrically administrated either omarigliptin at 30 mg/kg or varying doses of Cofrogliptin. Cofrogliptin inhibitory activity on plasma DPP-4 was assayed ex vivo in ob/ob mice. After a single dose, Cofrogliptin exhibited a much stronger inhibition capability of plasma DPP-4 than omarigliptin in a dose dependent manner.
Monkeys were intragastrically administrated either vehicle or Cofrogliptin (10 mg/kg) at a volume of 5 mL/kg. The ex vivo plasma DPP-4 inhibition was also assayed for Cofrogliptin in rhesus monkeys. After a single dose of 10 mg/kg, Cofrogliptin possessed the capability of plasma DPP-4 inhibition over 80% for at least 12 days. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (171.52 mM), Sonication is recommended.
|
| Inhibitors Related | Trelagliptin | Trelagliptin succinate | Sitagliptin | Saxagliptin hydrate | Teneligliptin hydrobromide | Sitagliptin phosphate monohydrate | Picolamine | Anagliptin | Linagliptin | Vildagliptin | Saxagliptin | Sitagliptin phosphate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States