CNX-774 NEW
| Price | $34 | $48 | $80 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: CNX-774 | CAS No.: 1202759-32-7 |
| Purity: 99.11% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | CNX-774 |
| 描述 | CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM). |
| 激酶實驗 | In vitro kinase assays: The p38α and p38β are assayed in 25 mM Tris-HCl, pH 7.5, containing 0.1 mM EGTA, with myelin basic protein (0.33 mg/mL) as substrate. Assays are performed either manually for 10 minutes at 30 °C in 50 μL incubations using [γ-33P]ATP, or with a Biomek 2000 Laboratory Automation Workstation in a 96-well format for 40 minutes at ambient temperature in 25 μL incubations using [γ-33P]ATP. The concentrations of ATP and magnesium acetate are 0.1 mM and 10 mM respectively. All assays are initiated with MgATP. Manual assays are terminated by spotting aliquots of incubation on to phosphocellulose paper, followed by immersion in 50 mM phosphoric acid. Robotic assays are terminated by the addition of 5 μL of 0.5 M phosphoric acid before spotting aliquots on to P30 filter mats. All papers are then washed four times in 50 mM phosphoric acid to remove ATP, once in acetone (manual incubations) or methanol (robotic incubations), and then dried and counted for radioactivity. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 2 mg/mL (4.0 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 93 mg/mL (186.2 mM) |
| 關鍵字 | Bruton tyrosine kinase | Btk | CNX-774 | B-cell | BCR | Inhibitor | inhibit | CNX774 | autoimmune |
| 相關產品 | evobrutinib | (±)-Zanubrutinib | CP-547632 | BMS-986142 | Edralbrutinib | Sunvozertinib | Ibrutinib | IBT6A | Orelabrutinib | Atuzabrutinib | Remibrutinib | CGI-1746 |
| 相關庫 | 高選擇性抑制劑庫 | 經典已知活性庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 抑制劑庫 | NO PAINS 化合物庫 | 腫瘤免疫治療小分子化合物庫 | 口服活性化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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