Product Details
Product Name:
CM-675 |
CAS No.:
1872466-47-1 |
Purity:
99.67% |
Supply Ability:
10g |
Release date:
2024/11/06 |
Product Introduction
Bioactivity
名稱 | CM-675 |
描述 | CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease. |
體外活性 | CM-675 (29a) demonstrates a pronounced time-dependent inhibitory effect on class I HDACs, particularly HDAC2. Its potency against HDAC1 also significantly enhances over time, showing increased inhibition (~1 log unit) at varying pre-incubation intervals: 673 nM at 30 minutes, 180 nM at 4 hours, and 69 nM at 6 hours[1]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 22.5 mg/mL (41.9 mM), Sonication and heating to 60℃ are recommended.
|
關(guān)鍵字 | CM675 | CM-675 | CM 675 |
相關(guān)產(chǎn)品 | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Sodium 4-phenylbutyrate | Curcumin | Theobromine | Apremilast | Indomethacin | Icariin | 4-Phenylbutyric acid | Theophylline | Doxofylline |
相關(guān)庫 | DNA 損傷和修復(fù)分子庫 | NF-κB 通路分子庫 | 經(jīng)典已知活性庫 | 表觀遺傳庫 | 染色質(zhì)修飾分子庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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