Clofazimine NEW
| Price | $50 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Clofazimine | CAS No.: 2030-63-9 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Clofazimine |
| 描述 | Clofazimine (NSC-141046) is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria. |
| 體外活性 | Administered bi-daily at 500 μg, Clofazimine accumulates at the highest concentrations in the spleen and liver, while significantly reduced levels are observed in the lungs. A dosage of 20 mg/kg of Clofazimine can prevent death by significantly decreasing the colony-forming unit (CFU) count in the lungs and spleen of C57BL/6 mice infected with the tuberculosis bacillus Mycobacterium tuberculosis H37Rv. The same dosage effectively lowers bacterial numbers in the liver, spleen, and lungs of C57BL/6 mice infected with the Mycobacterium avium strain TMC724. Moreover, 50 mg/kg of Liposomal Clofazimine in acute infection reduces CFUs in the spleen, liver, and lungs of mice harboring the Erdman strain of tuberculosis, exhibiting dose-dependency. |
| 體內(nèi)活性 | At a concentration of 1 μg/mL, Clofazimine inhibits the activity of J774A.1 macrophages in a dose-dependent manner. The compound targets neutrophils, activating phospholipase A2 which, in turn, increases the release of lysophosphatidylcholine and arachidonic acid from the neutrophil membrane. In macrophages, Clofazimine stabilizes lysosomal membranes and impedes the metabolism of Mycobacterium leprae within murine peritoneal macrophages. Additionally, Clofazimine exhibits a 90% inhibition rate on 20 strains of Mycobacterium tuberculosis with minimum inhibitory concentrations (MICs) of less than 1.0 μg/mL. It also suppresses the mitogen-induced proliferation of peripheral blood mononuclear cells. |
| 存儲條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 1 mg/mL, Sonication is recommended. |
| 關(guān)鍵字 | Clofazimine | NSC 141046 | Inhibitor | NSC141046 | Bacterial | Antibiotic | inhibit |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Doxycycline | Dimethyl sulfoxide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 抗病毒庫 | 藥物功能重定位化合物庫 | FDA 上市藥物庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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