Product Details
| Product Name:
CL097 |
CAS No.:
1026249-18-2 |
| Purity:
99.57% |
Supply Ability:
10g |
| Release date:
2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | CL097 |
| 描述 | CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. |
| 體外活性 | CL097 (0, 0.5, 2.5, 5, and 10 μg/mL) induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils[1]. CL097 (0.1 μM) induces activation of NF-κB in TLR7-transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells[3]. |
| 體內活性 | in NOD mice, CL097 (5 mg/kg, s.c.) causes a modest specific lysis of the target peptide (～25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 95 mg/mL (392.11 mM), Sonication is recommended.
|
| 關鍵字 | Immunological | CL-097 | inhibit | Oligonucleotide | Toll-like Receptor (TLR) | Peptide | TLR7 | Heterocycle | modulators | Inhibitor | CL 097 | Reactive Oxygen Species | TLR8 |
| 相關產品 | Sodium Thiocyanate | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid | α-Vitamin E | Hydroxychloroquine | Chloroquine phosphate | Glucosamine | D-(+)-Glucono-1,5-lactone | Chloranil | Lycopene | Naringenin |
| 相關庫 | NF-κB 通路分子庫 | 經典已知活性庫 | 膜蛋白靶向化合物庫 | 抗卵巢癌化合物庫 | 抗乳腺癌化合物庫 | 細胞焦亡化合物庫 | 抗前列腺癌化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗肝癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1450.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
United States