Product Details
| Product Name:
Cirsimaritin |
CAS No.:
6601-62-3 |
| Purity:
99.59% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Cirsimaritin |
| 描述 | Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. |
| 體外活性 | Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt [1]. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner [2]. |
| 體內活性 | Cirsimaritin significantly reduces anxiety in mice. The high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg)[3]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : Soluble
|
| 關鍵字 | γ-Aminobutyric acid Receptor | Cirsimaritin | inhibit | GABA Receptor | Inhibitor | Gamma-aminobutyric acid Receptor |
| 相關庫 | 黃酮類天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 疼痛相關化合物庫 | 稀有天然產(chǎn)物庫 | 植物來源化合物庫 | 高通量篩選天然產(chǎn)物庫 | 抗衰老化合物庫 | 離子通道庫 | 古代經(jīng)典名方目錄分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$7.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2019-08-31 |
United States