Cilastatin
Price | Get Latest Price | ||
Package | 1g | 5g | 10g |
Min. Order: | 1g |
Supply Ability: | 1000 |
Update Time: | 2025-01-16 |
Product Details
Product Name: Cilastatin | CAS No.: 82009-34-5 |
Min. Order: 1g | Purity: 98 |
Supply Ability: 1000 | Release date: 2025/01/16 |
Product Name: Cilastatin
Synonyms: Cilistatin Acid;(z)-7-[(2s)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(r-(r*,s*-(z)))-)carbonyl)amino);mk-791;CILASTATIN;Cilastain;(2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid;Cilastatin acid
CAS: 82009-34-5
MF: C16H26N2O5S
MW: 358.45
EINECS: 279-875-8
Product Categories: Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin . In a mouse model of systemic infection, cilastatin in combination with imipenem protects mice from S. aureus, E. coli, and P. aeruginosa infection. Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life. Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.
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- Since: 2024-03-12
- Address: Room 02-31, 13 / F, Building 9, Guannan Fuxing Medical Park Phase II, No.58, Guanggu Avenue, East La