1.1 Name

Chorionic Gonadotropin

1.2 Synonyms

1.3 CAS No.

9002-61-3

1.4 EINECS(EC#)

232-660-2

1.5 Molecular Formula

C17H28 (isomer)

General Description

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

2.1 Biochem/physiol Actions

Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.

2.2 Clinical Use

Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the ovaries. Ultrasonograms are used to determine proper follicle maturation before the administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this product is that it can be self-administered by the patient via SC injection.

2.3 Veterinary Drugs and Treatments

The veterinary product’s labeled indication is for “parenteral use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.” It has been used for other purposes in several species; refer to the Dosage section for more information.