CHMFL-PI4K-127 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: CHMFL-PI4K-127 | CAS No.: 2377604-81-2 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | CHMFL-PI4K-127 |
| Description | CHMFL-PI4K-127 (compound 15g) is a highly selective inhibitor of PfPI4K (Plasmodium falciparum PI4K kinase) with oral activity (IC50=0.9 nM) and exhibits strong inhibitory activity against Plasmodium falciparum 3D7 (EC50=25.1 nM), demonstrating significant anti-malaria effects. |
| In vitro | CHMFL-PI4K-127 (compound 15g) exhibits significant selectivity for PfPI4K over human lipid and protein kinases [1], with effective half-maximal concentration (EC50) values of 23-47 nM against various drug-resistant strains of P. falciparum [1]. |
| In vivo | CHMFL-PI4K-127 (compound 15g) exhibited significant antimalarial efficacy in both the blood stage (80 mg/kg) and liver stage (1 mg/kg) of Plasmodium infection in a rodent model when administered orally. In Balb/c mice infected with P. yoelii, varying dosages were tested over different periods. For the blood stage, daily doses of 0, 60, and 80 mg/kg for 7 days showed curative effects at 80 mg/kg, while 60 mg/kg resulted in suppressive effects with relapse after cessation. In the liver stage, single doses of 0, 1, 5, and 15 mg/kg showed that a 1 mg/kg dose provided full protection and cure, eliminating visible liver parasites at multiple time points post-treatment, indicating strong causal prophylactic efficacy. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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