Chlorprothixene NEW
| Price | $31 | $48 | $98 |
| Package | 100mg | 200mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Chlorprothixene | CAS No.: 113-59-7 |
| Purity: 99.69% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Chlorprothixene |
| 描述 | Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized. |
| 體外活性 | When Chlorprothixene acts on the brain, it inhibits the postsynaptic mesolimbic dopamine D1 and D2 receptors, reducing the release of hypothalamic and pituitary hormones. In mouse brains, Chlorprothixene reduces levels of 5HT, NE, and DA. At high doses, Chlorprothixene's effect on adrenal medulla and brain tissue can inhibit the action of nicotinic acid isopropylhydrazine, inducing the release of catecholamines for protective purposes. Additionally, Chlorprothixene has an inhibitory effect on acidic sphingomyelin in murine bronchial epithelial cells, promoting the repair of neuronal myelin concentration, thereby decreasing the incidence of inflammatory responses in mice with cystic fibrosis and also preventing infection by Pseudomonas aeruginosa. |
| 體內(nèi)活性 | Chlorprothixene induces Vero 76 cells, resulting in inhibited replication of SARS-CoV. It exhibits high affinity for the murine 5-HT6 receptor in stably transfected HEK-293 cells, with a Ki value of 3 nM, and for the transiently expressed murine 5-HT7 receptor in COS-7 cells, with a Ki value of 5.6 nM. Chlorprothixene has a strong binding affinity to histamine and dopamine receptors including D1, D2, D3, D5, and H1, with Ki values of 18 nM, 2.96 nM, 4.56 nM, 9 nM, and 3.75 nM, respectively. However, its affinity for the H3 receptor is weak, with a Ki value greater than 1000 nM. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 10 mg/mL (31.66 mM), Sonication is recommended. Ethanol : 27 mg/mL (85.5 mM) |
| 關(guān)鍵字 | Chlorprothixene | Inhibitor | inhibit | Bacterial | Dopamine Receptor | Histamine Receptor |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
| 相關(guān)庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | FDA 上市藥物庫(kù) | 抗癌上市藥物庫(kù) | GPCR靶點(diǎn)分子庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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