Chlorpropamide NEW
| Price | $31 |
| Package | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Chlorpropamide | CAS No.: 94-20-2 |
| Purity: 99.01% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Chlorpropamide |
| 描述 | Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. |
| 激酶實(shí)驗(yàn) | Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter. |
| 體內(nèi)活性 | At a concentration of 0.2 mM, chlorpropamide elevated the levels of fructose-2,6-bisphosphate (F-2,6-P2) in isolated hepatocytes from rats. The compound operates through a cyclic AMP-independent mechanism, enhancing insulin's inhibitory effect on glucagon-stimulated gluconeogenesis. Chlorpropamide significantly increased glucose metabolism and total lipid content, irrespective of insulin deficiency (30%) or presence (31%). |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 51 mg/mL (184.3 mM) DMSO : 55 mg/mL (198.74 mM) |
| 關(guān)鍵字 | Sodium potassium pump | inhibit | Na+/K+ ATPase | Chlorpropamide | Inhibitor |
| 相關(guān)產(chǎn)品 | Tirofiban hydrochloride monohydrate | Sodium oleate | Vismodegib | Vigabatrin | trans-Aconitic acid | Phlorizin | Probucol | Oleic acid | Revaprazan hydrochloride | Acridone | Esomeprazole Sodium | Trichlormethiazide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 藥物功能重定位化合物庫 | 線粒體靶向庫 | NO PAINS 化合物庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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