CH-223191 NEW
| Price | $56 | $98 | $178 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: CH-223191 | CAS No.: 301326-22-7 |
| Purity: 99.58% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | CH-223191 |
| 描述 | CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR). |
| 體外活性 | Daily oral administration of 10 mg/kg CH-223191 effectively prevents cytochrome P450 induction, wasting syndrome, and hepatotoxicity in mice caused by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. |
| 體內(nèi)活性 | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells, consequently reducing clonogenic survival and invasiveness. In neuron cells derived from human SK-N-SH, it counteracts the suppression of neuronal acetylcholinesterase expression induced by TCDD. Moreover, CH-223191 blocks the nuclear translocation and DNA binding of AhR mediated by TCDD and also inhibits the activation of cytochrome P450 enzyme activity induced by TCDD. Additionally, CH-223191 enhances the expression of ICAM-1 in endothelial cells and prevents the nuclear translocation of RelB. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 3.3 mg/mL (10 mM) DMSO : 60 mg/mL (179.97 mM) |
| 關(guān)鍵字 | AhR | Inhibitor | Aryl Hydrocarbon Receptor | inhibit | CH223191 | CH-223191 |
| 相關(guān)產(chǎn)品 | Nimodipine | Carbidopa monohydrate | Diosmin | (-)-Perillaldehyde | Prochloraz | Benzyl butyl phthalate | Skatole | L-Kynurenine | Indole-3-carbinol | Leflunomide | MeBIO | Mexiletine hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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