CH-223191 NEW
| Price | $56 | $98 | $178 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: CH-223191 | CAS No.: 301326-22-7 |
| Purity: 99.71% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | CH-223191 |
| Description | CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR). |
| In vitro | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH-223191 counteracts TCDD-induced inhibition of neuronal acetylcholinesterase expression. CH-223191 blocks TCDD-mediated nuclear translocation and AhR DNA binding, while also inhibiting TCDD-induced cytochrome P450 enzyme activity. Additionally, CH-223191 enhances ICAM-1 expression in endothelial cells and prevents RelB nuclear translocation. |
| In vivo | Oral administration of CH-223191 at 10 mg/kg per day effectively prevents dioxin (TCDD)-induced cytochrome P450-mediated wasting syndrome and hepatotoxicity in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 3.3 mg/mL (9.9 mM), Sonication is recommended. DMSO : 60 mg/mL (179.97 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | CH-223191 | CH223191 | ArylHydrocarbonReceptor | Aryl Hydrocarbon Receptor | AhR |
| Inhibitors Related | Nimodipine | Carbidopa monohydrate | Diosmin | (-)-Perillaldehyde | Prochloraz | Benzyl butyl phthalate | L-Kynurenine | Indole-3-carbinol | MeBIO | Leflunomide | DiMNF | Mexiletine hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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