Cephaeline NEW
| Price | $189 | $372 | $549 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Cephaeline | CAS No.: 483-17-0 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Cephaeline |
| 描述 | Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis. |
| 體外活性 | We compared the transcriptomes of primary CLL cells cocultured or not with protective bone marrow stromal cells (BMSCs) and found that oxidative phosphorylation, mitochondrial function, and hypoxic signaling undergo most significant dysregulation in non-protected CLL cells, with the changes peaking at 6-8 h, directly before induction of apoptosis. A subset of CLL patients displayed a gene expression signature resembling that of cocultured CLL cells and had significantly worse progression-free and overall survival. To identify drugs blocking BMSC-mediated support, we compared the relevant transcriptomic changes to the Connectivity Map database. Correlation was found with the transcriptomic signatures of the cardiac glycoside ouabain and of the ipecac alkaloids emetine and Cephaeline. These compounds were highly active against protected primary CLL cells (relative IC50's 287, 190, and 35 nM, respectively) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis. We tested emetine in a murine model of CLL and observed decreased CLL cells in peripheral blood, spleen, and bone marrow, recovery of hematological parameters and doubling of median survival (31.5 vs. 15 days, P = 0.0001). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 33.33 mg/mL (71.43 mM), Sonication is recommended. |
| 關(guān)鍵字 | NSC 32944 | inhibit | Inhibitor | NSC32944 | Ebola | Filovirus | phenolic | alkaloid | virus | Influenza Virus | NSC-32944 | Zika | Cephaeline |
| 相關(guān)產(chǎn)品 | Phenytoin sodium | α-Vitamin E | Anthraquinone | Nitazoxanide | L-Lysine | 2-Phenylethanol | Curcumin | Hydroxycitric acid tripotassium hydrate | Naringenin | Salcomine | 4-Phenylbutyric acid | Crystal Violet |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 生物堿類天然產(chǎn)物庫 | 植物來源化合物庫 | 抗病毒庫 | 天然產(chǎn)物庫 | 煙草單體化合物庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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