Cedazuridine hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Cedazuridine hydrochloride | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Cedazuridine hydrochloride |
| Description | Cedazuridine (E7727) (Compound 7a) hydrochloride, an orally active cytidine deaminase (CDA) inhibitor with an IC50 of 0.4 μM, can be used for cancer research [1]. |
| In vitro | Cedazuridine (Compound 7a) demonstrates superior acid stability [1], and at concentrations of 0-10 μM over 72 hours, it does not enhance the growth inhibition effects of AZA (5-Azacytidine) in AML cell lines [2]. |
| In vivo | Cedazuridine, when administered orally at a dose of 3 mg/kg daily for 7 days, in conjunction with 2.5 mg/kg AZA, induced tumor regression in both MOLM-13 cell line-derived (CDX) and patient-derived xenograft (PDX) mouse models of leukemia. Female NSGS mice, aged 6–8 weeks, were used for these experiments, demonstrating not only a reduction in leukemic expansion in synergy with AZA in a CDX setup but also showcasing preliminary safety and efficacy in a primary AML PDX scenario. Further investigations in NSGS male mice, with Cedazuridine doses ranging from 1 to 30 mg/kg combined with 2.5 mg/kg AZA, revealed a dose-dependent increase in the bioavailability (AUC) of orally administered AZA, compared to its standard intraperitoneal administration, suggesting enhanced pharmacokinetic performance. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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