Product Details
| Product Name:
CC-90001 |
CAS No.:
1403859-14-2 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2024/11/14 |
Product Introduction
Bioactivity
| 名稱(chēng) | CC-90001 |
| 描述 | CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2. |
| 體外活性 | CC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts[1]. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM)[2]. |
| 體內(nèi)活性 | CC-90001 effectively mitigates lung fibrosis by significantly decreasing lung collagen metrics and lowering disease-induced α-SMA increases to nearly baseline levels in a house dust mite-induced lung fibrosis model. Moreover, when administered at a dosage of 3 mg/kg b.i.d., it hampers fibrosis development, evidenced by a notable reduction of 48% in collagen and 53% in α-smooth muscle actin (α-SMA) within a steatohepatitis model. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 125 mg/mL (388.90 mM)
|
| 關(guān)鍵字 | pulmonary | N-terminal | kinase | JNK1 | JNK | IPF | Inhibitor | inhibit | idiopathic | fibrosis | c-Jun | CC-90001 | CC90001 | CC 90001 |
| 相關(guān)產(chǎn)品 | JNK-IN-13 | Urolithin B | Astragaloside IV | SKLB-163 | SP600125 | (-)-Bornyl acetate | Anisomycin | SR-3306 | (E)-Ferulic acid methyl ester | Bentamapimod | Ginsenoside Re | TCS JNK 5a |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 疼痛相關(guān)化合物庫(kù) | 激酶抑制劑庫(kù) | 抗肥胖化合物庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 免疫/炎癥分子化合物庫(kù) | 臨床期小分子藥物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$51.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-14 |
|
|
$1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
|
|
$0.01/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-01-07 |
United States