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Postion:Product Catalog >CC-90001
CC-90001
  • CC-90001

CC-90001 NEW

Price $159 $339 $537
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: CC-90001 CAS No.: 1403859-14-2
Purity: 99.87% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameCC-90001
DescriptionCC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
In vitroCC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts[1]. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM)[2].
In vivoCC-90001 effectively mitigates lung fibrosis by significantly decreasing lung collagen metrics and lowering disease-induced α-SMA increases to nearly baseline levels in a house dust mite-induced lung fibrosis model. Moreover, when administered at a dosage of 3 mg/kg b.i.d., it hampers fibrosis development, evidenced by a notable reduction of 48% in collagen and 53% in α-smooth muscle actin (α-SMA) within a steatohepatitis model.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 125 mg/mL (388.90 mM)
Keywordspulmonary | N-terminal | kinase | JNK1 | JNK | IPF | Inhibitor | inhibit | idiopathic | fibrosis | c-Jun | CC-90001 | CC90001 | CC 90001
Inhibitors RelatedJNK-IN-13 | Urolithin B | Astragaloside IV | SKLB-163 | SP600125 | (-)-Bornyl acetate | Anisomycin | SR-3306 | (E)-Ferulic acid methyl ester | Bentamapimod | Ginsenoside Re | TCS JNK 5a
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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