CBR-470-1 NEW
| Price | $62 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: CBR-470-1 | CAS No.: 2416095-06-0 |
| Purity: 98.03% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | CBR-470-1 |
| 描述 | CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protects SH-SY5Y neuronal cells from MPP+-induced cytotoxicity by activating the Keap1-Nrf2 cascade. cytotoxicity induced by MPP+. |
| 體外活性 | In IMR32 cells, CBR-470-1, when applied for 24 hours at concentrations ranging from 0.01 to 10 μM, demonstrates an EC50 of 962 nM in the ARE-LUC reporter assay[1].Furthermore, CBR-470-1 induces a dose- and time-dependent accumulation of Nrf2 protein in IMR32 cells when administered at concentrations between 0.5 and 20 μM over a period of 1 to 24 hours[1].In SH-SY5Y cells, a 4-hour treatment with CBR-470-1 at 10 μM activates the Nrf2 signaling cascade[2].Moreover, a 2-hour exposure to CBR-470-1 at 10 μM inhibits MPP+-induced oxidative injury in SH-SY5Y neuronal cells[2]. |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (273.30 mM), Sonication is recommended. |
| 關(guān)鍵字 | CBR4701 | CBR-470-1 | CBR 470 1 |
| 相關(guān)產(chǎn)品 | TBHQ | L-Cystine dihydrochloride | Mangiferin | Methyl 3,4-dihydroxybenzoate | Pyridoxine | Resveratrol | Luteolin | Curcumin | Ezetimibe | Oltipraz | Pyridoxine hydrochloride | ML385 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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