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Postion:Product Catalog >CB-6644
CB-6644
  • CB-6644

CB-6644 NEW

Price $228 $579 $829
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: CB-6644 CAS No.: 2316817-88-4
Purity: 96.33% Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱CB-6644
描述CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex. It specifically interacts with RUVBL1/2 in cancer cells and blocks the ATPase activity of RUVBL1/2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1].
體外活性METHODS: HCT116, NCI-1975, and HT29 cells were treated with CB-6644 (100nM-500nM) and allowed to form colonies within 3 weeks. RESULTS CB-6644 was able to effectively kill cells with an EC50 range of 41 ~ 785 nM. [1]
體內(nèi)活性METHODS: Plasma concentrations and tumor growth were measured in nude female mice or after a single intravenous dose (0.5 mg/kg) of CB-6644. RESULTS CB-6644 can significantly inhibit tumor growth and has little effect on body weight. [1]
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 1 mg/mL, Sonication is recommended.
關鍵字CB6644 | CB-6644 | Inhibitor | CB 6644 | inhibit
相關庫經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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