Description of Calcium folinate（Leucovorin Calcium） from Watson Biotechnology Co., Ltd

Specifications(COA) of Calcium folinate （Leucovorin Calcium） CAS 1492-18-8

Calcium folinate, also known as leucovorin, is a medication with several important medical applications:

1. Chemotherapy Rescue: It's primarily used to reduce the toxic effects of methotrexate, a chemotherapy drug. Methotrexate inhibits the enzyme dihydrofolate reductase, which is necessary for DNA synthesis. Calcium folinate "rescues" normal cells by providing a source of folate, allowing them to continue DNA synthesis, thereby mitigating the harmful effects of methotrexate.

2. Enhancement of Chemotherapy: In some cases, calcium folinate is used to enhance the effects of chemotherapy drugs like 5-fluorouracil (5-FU). It stabilizes the binding of 5-FU to the enzyme thymidylate synthase, increasing its effectiveness against cancer cells.

3. Treatment of Folic Acid Deficiency: Calcium folinate is also used to treat or prevent folic acid deficiency when normal folic acid supplementation is inadequate, such as in certain types of anemia.

4. Overdose of Folate Antagonists: It is used as an antidote for overdoses of folate antagonists, like methotrexate, or in cases where there is an increased risk of toxicity from these drugs.

5. Pernicious Anemia: It may be used in combination with other medications for the treatment of pernicious anemia, although it’s not the primary treatment.

These applications make calcium folinate a versatile and critical drug in both oncology and other medical fields.

Founded in 2006 and headquartered in Wuhan, Hubei, China, Watson Biotechnology Co., Ltd is a leading manufacturing powerhouse specializing in the production of Active Pharmaceutical Ingredients (APIs) and Intermediates, Food and Feed Additives, Agricultural and Aquaculture chemicals, and Fine Chemicals. As a dedicated factory, our operations are driven by a commitment to excellence and innovation, ensuring that our products meet the highest standards of quality and compliance.

With a robust team of over 100 skilled professionals, Watson Biotechnology has established itself as a trusted name in the industry. Our products are meticulously crafted to align with international standards such as USP (United States Pharmacopeia), EP (European Pharmacopoeia), and BP (British Pharmacopoeia), guaranteeing reliability and efficacy.

At Watson Biotechnology, we pride ourselves on our cutting-edge facilities and state-of-the-art technology, which enable us to deliver superior products that cater to a diverse range of needs across various sectors. Our dedication to continuous improvement and customer satisfaction drives us to maintain stringent quality control processes and foster an environment of innovation and growth.

Watson Biotechnology Co., Ltd is a professional manufacturer which provide Calcium folinate（Leucovorin Calcium）with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Calcium folinate（Leucovorin Calcium）.