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Postion:Product Catalog >CA-4948
CA-4948
  • CA-4948

CA-4948 NEW

Price $30 $70 $89
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-01

Product Details

Product Name: CA-4948 CAS No.: 1801344-14-8
Purity: 99.62% Supply Ability: 10g
Release date: 2024/11/01

Product Introduction

Bioactivity

名稱CA-4948
描述CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
體外活性CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines.?Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays.?CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.?CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure.?The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度H2O : < 0.1 mg/mL (insoluble)
DMSO : 27.78 mg/mL (56.52 mM), Sonication is recommended.
關(guān)鍵字rheumatoid | inflammation | CD135 | inhibit | IL-1R associated kinase | CA4948 | lymphoma | Interleukin-1 receptor associated kinase | Fms like tyrosine kinase 3 | FLT3 | arthritis | Inhibitor | Cluster of differentiation antigen 135 | Myd88 | CA 4948 | IL-1R | IRAK | Toll | CA-4948
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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