Product Details
| Product Name:
C004019 |
CAS No.:
2417159-57-8 |
| Purity:
99.37% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | C004019 |
| 描述 | C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases. |
| 體外活性 | C004019 induced a robust tau clearance via promoting its ubiquitination-proteasome-dependent proteolysis in HEK293 cells with stable or transient overexpression of human tau (hTau), and in SH-SY5Y that constitutively overexpress hTau.[1] |
| 體內(nèi)活性 | C004019 induced a robust tau clearance in vivo by intracerebral ventricular infusion. Most importantly, both single-dose and multiple-doses (once per 6 days for a total of 5 times) subcutaneous administration of C004019 remarkably decreased tau levels in the brains of wild-type, hTau-transgenic and 3xTg-AD mice with the improvement of synaptic and cognitive functions.[1] |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 關(guān)鍵字 | C004019 | C-004019 | C 004019 |
| 相關(guān)產(chǎn)品 | Flubendazole | Mebendazole | N-Phenylbenzylamine | 4-Isopropoxybenzoic acid | ARV-471 | Oxfendazole | Methylene Blue | Methylene Blue trihydrate | Paclitaxel | 4'-Demethylepipodophyllotoxin |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 微管靶向化合物庫(kù) | 已知活性化合物庫(kù) | 細(xì)胞骨架化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States