BYAKANGELICIN NEW
| Price | $31 | $73 | $123 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: BYAKANGELICIN | CAS No.: 482-25-7 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | BYAKANGELICIN |
| 描述 | BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use. |
| 細(xì)胞實(shí)驗(yàn) | Cultures of human hepatocytes and a hepatoma cell line (Huh7 cells) were used.?mRNA and protein levels were measured by quantitative reverse transcription-polymerase chain reaction and Western blot.?Plasmid constructs and mutants were prepared by cloning and site-directed mutagenesis.?Reporter (luciferase) activity was determined by transient co-transfection experiments[1]. |
| 動(dòng)物實(shí)驗(yàn) | Induction of diabetes and drug treatment: Experimental diabetes was induced by a single injection of STZ (60 mg/kg), in 0.1 ml of 0.01 M citrate buffer (pH 4.5) into the tail vein of male Sprague-Dawley rats that had been fasted overnight.?Blood glucose was determined with a commercial blood glucose oxidase analysis kit.?Rats with blood glucose concentrations higher than 300 mg/dL were selected and considered to be diabetic.?Beginning with day 3 after the injection of STZ, diabetic rats were dosed with byakangelicin and epalrestat suspended in 5 g/dL gum arabic once a day throughout the experimental periods.?Controls and a group of normal rats were given the vehicle alone.?Animals were sacrificed by ether anesthesia and tissues were surgically removed, weighed and processed either for GC determination of polyol contents or for ATPase assay[2]. |
| 體外活性 | In human primary hepatocytes, byakangelicin markedly induced the expression of CYP3A4 both at the mRNA level (approximately fivefold) and the protein level (approximately threefold) but did not affect expression of human pregnane X receptor (hPXR).?Byakangelicin activated CYP3A4 promoter in a concentration-dependent manner (EC?? = 5 μM), and this activation was enhanced by co-transfection with hPXR.?The eNR4 binding element in the CYP3A4 promoter was required for the transcriptional activation of CYP3A4 by byakangelicin[1]. |
| 體內(nèi)活性 | Cataract formation and galactitol accumulation in the lenses of rats fed a 30% galactose diet were significantly prevented by intragastric (i.g.) administration of byakangelicin at a dose of 100 mg/kg for 14 days. Administration of the drug for 18 days was found to suppress sorbitol accumulation and cause a significant reversal of depleted myo-inositol contents as well as Na(+),K(+)ATPase activity in the sciatic nerves of streptozotocin-induced diabetic rats. In rats, byakangelicin is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use[2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (134.6 mM) |
| 關(guān)鍵字 | inhibit | Inhibitor | BYAKANGELICIN |
| 相關(guān)產(chǎn)品 | MK 0434 | Alconil | Epalrestat | D-Methionine sulfoxide | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | Tolrestat | Lidorestat | Alpha-Estradiol | Isoliquiritigenin | Finasteride | Epristeride | Dutasteride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 植物來源化合物庫 | 中國(guó)藥典收錄天然產(chǎn)物庫 | 天然產(chǎn)物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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