Product Name:    Busulfan

Synonyms:    BUSULFAN;tetramethylene bis(methanesulfonate);myleran;busulfex;busulphan;1,4-dimethanesulfonoxybutane;1，4-Bis(methyl sulfonoxy)butane;1,4-BUTANEDIOL DIMETHANESULFONATE

CAS:    55-98-1

MF:    C6H14O6S2

MW:    246.3

EINECS:    200-250-2

Product Categories:    MYLERAN;Antitumors for Research and Experimental Use;Biochemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;55-98-1

Chemically, busulfan is classified as an alkyl sulfonate. One or both of the methylsulfonate ester moieties can be displaced by the nucleophilic N7 of guanine, leading to monoalkylated and cross-linked DNA. The extent of alkyl sulfonate–mediated DNA interstrand cross-linking has been shown to vary with the length of the alkyl chain between sulfonate esters, with the tetramethylene-containing busulfan showing less interstrand cross-linking capability than hexamethylene, methylene, or octamethylene analogues. Intrastrand cross-linking also occurs, preferentially at 5′-GA-3′ but also at 5′-GG-3′ sequences. Alkylation of Cys sulfhydryl groups is yet another mechanism of cytotoxicity.