Product Details
Product Name:
BRD6989 |
CAS No.:
642008-81-9 |
Purity:
99.43% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | BRD6989 |
Description | BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. |
In vitro | Pretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production (EC50: ~1 μM). BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs. BRD6989 (5 μM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells. BRD6989 (5 μM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 11 mg/mL (41.61 mM)
|
Keywords | CDK8 | Inhibitor | inhibit | CDK19 | IL-10 | inflammatory | Cyclin dependent kinase | BMDCs | BRD6989 | Interleukin Related | BRD 6989 | cortistatin-A | BRD-6989 | CDK |
Inhibitors Related | Sodium Thiocyanate | Disulfiram | Inosine pranobex | Amlexanox | Balsalazide sodium hydrate | Dexamethasone acetate | L-Arginine | α-Terpineol | Diallyl disulfide | Linalool | Sodium Oxamate | Abemaciclib |
Related Compound Libraries | Bioactive Compound Library | Cytokine Inhibitor Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Pyroptosis Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$30.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |