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Postion:Product Catalog >BRD6989
BRD6989
  • BRD6989

BRD6989 NEW

Price $30 $67 $98
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: BRD6989 CAS No.: 642008-81-9
Purity: 99.43% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameBRD6989
DescriptionBRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.
In vitroPretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production (EC50: ~1 μM). BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs. BRD6989 (5 μM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells. BRD6989 (5 μM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 11 mg/mL (41.61 mM)
KeywordsCDK8 | Inhibitor | inhibit | CDK19 | IL-10 | inflammatory | Cyclin dependent kinase | BMDCs | BRD6989 | Interleukin Related | BRD 6989 | cortistatin-A | BRD-6989 | CDK
Inhibitors RelatedSodium Thiocyanate | Disulfiram | Inosine pranobex | Amlexanox | Balsalazide sodium hydrate | Dexamethasone acetate | L-Arginine | α-Terpineol | Diallyl disulfide | Linalool | Sodium Oxamate | Abemaciclib
Related Compound LibrariesBioactive Compound Library | Cytokine Inhibitor Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Pyroptosis Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$30.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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