Boldine NEW
| Price | $35 | $44 |
| Package | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Boldine | CAS No.: 476-70-0 |
| Purity: 98.53% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Boldine |
| 描述 | Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities. |
| 細(xì)胞實(shí)驗(yàn) | Sulforhodamine B assay, Tetrazolium reduction assay, Flow Cytometry Analysis, Ecto-5'-nucleotidase activity and Western blot assay were performed[1]. |
| 動(dòng)物實(shí)驗(yàn) | Vascular reactivity was studied in mouse aortas from db/db diabetic and normal mice.?Reactive oxygen species (ROS) production, angiotensin AT1 receptor localization and protein expression of oxidative stress markers in the vascular wall were evaluated by dihydroethidium fluorescence, lucigenin enhanced-chemiluminescence, immunohistochemistry and Western blot respectively.?Primary cultures of mouse aortic endothelial cells, exposed to high concentrations of glucose (30?mmol L(-1) ) were also used[2]. |
| 體外活性 | Boldine was able to reduce cell viability and cell proliferation in T24 cells.?In addition, boldine arrests the cell cycle at G2/M-phase and cause cell death by apoptosis.?Boldine-induced inhibition of cell growth and cell cycle arrest appears to be linked to inactivation of extracellular signal-regulated kinase protein (ERK).?Additionally, the efficacy of boldine in apoptosis-induced in T24 cells is correlated with modulation of AKT (inactivation) and glycogen synthase kinase-3β (GSK-3β) (activation) proteins[1]. |
| 體內(nèi)活性 | Boldine reduced oxidative stress and improved endothelium-dependent relaxation in aortas of diabetic mice largely through inhibiting ROS overproduction associated with Ang II-mediated BMP4-dependent mechanisms[2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 65 mg/mL (198.55 mM) |
| 關(guān)鍵字 | Boldine | inhibit | Inhibitor |
| 相關(guān)產(chǎn)品 | Narlumosbart | NFATc1-IN-1 | Alisol B | Denosumab |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 中藥單體化合物庫 | 神經(jīng)退行性疾病化合物庫 | 生物堿類天然產(chǎn)物庫 | 植物來源化合物庫 | 天然產(chǎn)物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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