BMS 193885 NEW
| Price | $840 | $3360 |
| Package | 10mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: BMS 193885 | CAS No.: 679839-66-8 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | BMS 193885 |
| Description | BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM. |
| In vitro | BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor[1]. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y[1]. |
| In vivo | BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : <13.62 mg/mL DMSO : 63 mg/mL (92.5 mM) |
| Keywords | BMS 193885 | BMS-193885 |
| Inhibitors Related | AC-263093 | HT-2157 | Galanin (1-16), mouse, porcine, rat | L 152804 | GW438014A | Peptide YY (PYY) (3-36), human | Selvigaltin | SF-22 | JNJ-31020028 | DF-1012 FA | AR-M 1896 Acetate | AC-099 hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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