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Postion:Product Catalog >Biochemical Engineering>Polypeptide>Bivalirudin
Bivalirudin
  • Bivalirudin

Bivalirudin

Price $1
Package 1piece
Min. Order: 1piece
Supply Ability: 1000
Update Time: 2025-04-25

Product Details

Product Name: Bivalirudin CAS No.: 128270-60-0
Min. Order: 1piece Purity: 99%
Supply Ability: 1000 Release date: 2025/04/25

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Property Description

Chemical Name:Bivalirudin

CAS:128270-60-0

Molecular Formula C<sub>98</sub>H<sub>138</sub>N<sub>24</sub>O<sub>33</sub>

Molecular Weight:2180.28 g/mol

Appearance:White to off-white powder

Solubility:Soluble in water and saline; insoluble in organic solvents (e.g., ethanol, acetone)

Stability:Stable under recommended storage conditions (2–8°C); avoid prolonged exposure to high temperatures or humidity.

Mode of Action:Direct thrombin inhibitor (reversible binding to both free and clot-bound thrombin).

Pharmacological Use:Anticoagulant for percutaneous coronary intervention (PCI) and acute coronary syndromes (ACS).

Half-life:~25 minutes (in patients with normal renal function).

Origin:Synthetic 20-amino acid peptide analog of hirudin (derived from medicinal leech saliva).

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Bivalirudin is a synthetic peptide anticoagulant designed to mimic hirudin's action. It reversibly inhibits thrombin, preventing fibrin formation and thrombus development. Clinically, it is used as an alternative to heparin (with or without glycoprotein IIb/IIIa inhibitors) during PCI, particularly in patients with heparin-induced thrombocytopenia (HIT). Its short half-life and predictable pharmacokinetics make it suitable for acute procedures.

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Test ParameterSpecificationTest MethodReference Standard
AppearanceWhite to off-white powderVisual inspectionUSP/EP
IdentificationComplies (HPLC/MS or FTIR)HPLC/MS or FTIRUSP/EP
Assay (Purity)≥ 98.0% (HPLC area percentage)RP-HPLC (C18 column)USP/EP
Related SubstancesTotal impurities ≤ 2.0%
Single impurity ≤ 1.0%
HPLC (gradient elution)ICH Q3A/B
Water Content≤ 6.0% (Karl Fischer titration)Karl FischerUSP <921>
Residual SolventsMeets ICH Q3C limits (if applicable)GC (Headspace)ICH Q3C
Heavy Metals≤ 20 ppmICP-MS / USP <231>USP/EP
Microbial LimitsTotal aerobic count ≤ 100 CFU/g
Yeast/mold ≤ 50 CFU/g
No pathogens detected
Microbial enumerationUSP <61>, <62>
Endotoxin< 10 EU/mgLAL test (Gel Clot or Kinetic)USP <85>
pH (1% solution)5.0 – 7.0Potentiometric methodUSP <791>
Specific Rotation-85° to -95° (c=1 in water)PolarimetryUSP <781>
Peptide Content≥ 90.0% (by amino acid analysis)AAA (Amino Acid Analysis)USP/EP
Biological Activity≥ 90% (thrombin inhibition assay)Chromogenic substrate assayIn-house validated

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Company Profile Introduction

Wuhan Hao Rong Biotechnology Co., Ltd., located in East Lake high tech Development Zone, Wuhan, is a company specializing in the production and operation of chemical raw materials, flavors and fragrances, food additives, agrochemicals and other products. The company has first-class production equipment, advanced production technology, scientific management system, perfect detection means, and an excellent R & D team. The R & D center of the company has a technical team specialized in research and development, as well as a number of advanced detection, experiment and pilot equipment, and has established a good technical support relationship with a number of scientific research institutions, with strong technical force. The company has a wide range of products, in line with the quality of survival, service and development, customer-centric, integrity management philosophy, do our best to provide customers with quality and cheap raw materials. In addition, haorong also helps customers develop and implement customized system solutions. In these core areas of the chemical industry, haorong's core expertise covers chemicals and application technology, flexible asset management and customized services.

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  • Since: 2019-11-21
  • Address: Room E020, 4th Floor (1-3), Building 5, International Enterprise Center, No.1 Guanshan Second Road,
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