
Bivalirudin
Price | $1 |
Package | 1piece |
Min. Order: | 1piece |
Supply Ability: | 1000 |
Update Time: | 2025-04-25 |
Product Details
Product Name: Bivalirudin | CAS No.: 128270-60-0 |
Min. Order: 1piece | Purity: 99% |
Supply Ability: 1000 | Release date: 2025/04/25 |
Property Description
Chemical Name:Bivalirudin
CAS:128270-60-0
Molecular Formula C<sub>98</sub>H<sub>138</sub>N<sub>24</sub>O<sub>33</sub>
Molecular Weight:2180.28 g/mol
Appearance:White to off-white powder
Solubility:Soluble in water and saline; insoluble in organic solvents (e.g., ethanol, acetone)
Stability:Stable under recommended storage conditions (2–8°C); avoid prolonged exposure to high temperatures or humidity.
Mode of Action:Direct thrombin inhibitor (reversible binding to both free and clot-bound thrombin).
Pharmacological Use:Anticoagulant for percutaneous coronary intervention (PCI) and acute coronary syndromes (ACS).
Half-life:~25 minutes (in patients with normal renal function).
Origin:Synthetic 20-amino acid peptide analog of hirudin (derived from medicinal leech saliva).
Bivalirudin is a synthetic peptide anticoagulant designed to mimic hirudin's action. It reversibly inhibits thrombin, preventing fibrin formation and thrombus development. Clinically, it is used as an alternative to heparin (with or without glycoprotein IIb/IIIa inhibitors) during PCI, particularly in patients with heparin-induced thrombocytopenia (HIT). Its short half-life and predictable pharmacokinetics make it suitable for acute procedures.
Test Parameter | Specification | Test Method | Reference Standard |
---|---|---|---|
Appearance | White to off-white powder | Visual inspection | USP/EP |
Identification | Complies (HPLC/MS or FTIR) | HPLC/MS or FTIR | USP/EP |
Assay (Purity) | ≥ 98.0% (HPLC area percentage) | RP-HPLC (C18 column) | USP/EP |
Related Substances | Total impurities ≤ 2.0% Single impurity ≤ 1.0% | HPLC (gradient elution) | ICH Q3A/B |
Water Content | ≤ 6.0% (Karl Fischer titration) | Karl Fischer | USP <921> |
Residual Solvents | Meets ICH Q3C limits (if applicable) | GC (Headspace) | ICH Q3C |
Heavy Metals | ≤ 20 ppm | ICP-MS / USP <231> | USP/EP |
Microbial Limits | Total aerobic count ≤ 100 CFU/g Yeast/mold ≤ 50 CFU/g No pathogens detected | Microbial enumeration | USP <61>, <62> |
Endotoxin | < 10 EU/mg | LAL test (Gel Clot or Kinetic) | USP <85> |
pH (1% solution) | 5.0 – 7.0 | Potentiometric method | USP <791> |
Specific Rotation | -85° to -95° (c=1 in water) | Polarimetry | USP <781> |
Peptide Content | ≥ 90.0% (by amino acid analysis) | AAA (Amino Acid Analysis) | USP/EP |
Biological Activity | ≥ 90% (thrombin inhibition assay) | Chromogenic substrate assay | In-house validated |
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$5.00/1Box |
VIP1Y
|
Hebei Jiafan Trading Company Limited
|
2024-12-31 | |
$0.00/1Box |
VIP1Y
|
American HealthyMorph LLC
|
2024-12-26 | |
$37.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$10.00/1KG |
VIP7Y
|
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-11-19 | |
$0.00/1BOX |
VIP1Y
|
Shandong Huizhihan Supply Chain Co., Ltd
|
2024-11-12 | |
$0.00/1kg |
VIP2Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-16 | |
$0.00/1Box |
Shanghai Affida new material science and technology center
|
2024-04-12 | ||
$28.00/1box |
Shanghai Getian Industrial Co., LTD
|
2024-04-11 | ||
$30.00/1box |
hebei hongtan Biotechnology Co., Ltd
|
2024-03-20 | ||
$10.00/1kg |
Nantong Guangyuan Chemicl Co,Ltd
|
2023-11-15 |
- Since: 2019-11-21
- Address: Room E020, 4th Floor (1-3), Building 5, International Enterprise Center, No.1 Guanshan Second Road,
+86-18565342920
sales@chembj.net